Immunological Antagonism Between Psoriasis and Atopic Dermatitis: Pathways, Clinical Implications, and Therapeutic Perspectives

Targeted biologics have proven to be highly effective treatments for both psoriasis and atopic dermatitis; however, they may occasionally induce the onset of the opposite disease phenomenon known as paradoxical reaction. The underlying mechanisms of these reactions remain largely unclear. This review summarizes all currently reported cases of paradoxical reactions and integrates findings from recent sequencing studies to elucidate the latest progress in this field, raising new concerns for dermatologists regarding the long-term use of biological therapies.