Shokouh Gheibi, Omid Rezaei, Morvarid Ahadi
Coronavirus Disease 2019 (COVID-19) has been associated with both acute and long- term complications, spanning cardiorespiratory and neuropsychiatric domains. The neuropsychiatric sequelae may stem from immune system dysregulation, inflammatory cytokines, and psychosocial stressors, including threats to personal health, economic stability, and social standing. This case report presents a 55-year-old male with no prior psychiatric history who developed treatment-resistant depression following COVID-19 infection. The study emphasizes the psychological repercussions of the pandemic, particularly in individuals with fragile premorbid personality structures