Maria Neyze Martins Fernandes, Andreza Gysllaynny Delmondes Saraiva, Nathylle Régia de Sousa Caldas, Hercules Pereira Coelho, Maria do Socorro Vieira Lopes, Rita Neuma Dantas Cavalcante de Abreu, Woneska Rodrigues Pinheiro, Luis Rafael Leite Sampaio
these results suggest that Copaifera langsdorffii Desf. oleoresin has antioxidant activity and may protect against oxidative stress in skin lesions of aloxan-induced diabetic rats.
OBJECTIVES: to assess the antioxidant effect of topically applied oleoresin from Copaifera langsdorffii Desf. on skin lesions in alloxan-induced diabetic rats.
METHODS: experiments were conducted on 200-300-gram adult male Wistar rats induced with diabetes by aloxan. A 7-millimeter metal punch was used for surgical circular epidermal excision. Animals were divided into five groups of five and treated with saline solution, mineral oil, 10% copaiba oil, essential fatty acids, or absolute copaiba oleoresin for one, seven, or 14 days. Malondialdehyde (MDA), nitrite, and glutathione (GSH) peroxidase concentrations were assessed to investigate oxidative activity progression. Tests were performed on animals approved by CEUA-URCA.
RESULTS: Copaifera langsdorffii Desf significantly reduced MDA and nitrite while increasing GSH. Groups treated with oleoresin, both 10% and absolute, improved assessed parameters.
CONCLUSIONS: these results suggest that Copaifera langsdorffii Desf. oleoresin has antioxidant activity and may protect against oxidative stress in skin lesions of aloxan-induced diabetic rats.