Varun H, Adarshlata Singh, Bhushan Madke, Naman Kacchawa, Aryan Pal
BFP reactions are most common in autoimmune diseases, particularly SLE, SS, CTD, and RA, and typically present with low TRUST titers. ANA-positive BFP patients exhibit a broad autoantibody profile, while ANA-negative patients show limited positivity. Comprehensive clinical and autoantibody evaluation is essential to avoid misdiagnosis and unnecessary treatment.
Secondary syphilis is a clinical mimic with considerable morphological variability. We describe a man in his early 50s with a generalised papulosquamous eruption, constitutional symptoms and generalised lymphadenopathy, notably without palmoplantar involvement. Syphilis serology was strongly reactive, and histopathology demonstrated a plasma cell-rich superficial and deep perivascular and peri-adnexal infiltrate. This case illustrates the importance of considering secondary syphilis in generalised papulosquamous eruptions despite the absence of classical palmoplantar lesions.