Emma Louise Palatsides, Dibya Himali, Lachlan Cribb, Gina M. Peloso, Joanne Ryan, Qiong Yang, Charles S. Decarli, Alexa S. Beiser, Sudha Seshadri, Marina Cavuoto, Stephanie Yiallourou, Andrée‐Ann Baril, Jayandra J. Himali, Matthew Paul Pase
BACKGROUND AND OBJECTIVES: haplotype was associated with cognition, brain volumes, or incident dementia. METHODS: and incident all-cause dementia risk. Data analysis spanned February 2023 to July 2025. RESULTS: = 0.012, N = 114,868, incident cases = 5,625) compared with homozygote majors. DISCUSSION: haplotype (homozygote minors or heterozygotes) was linked to better verbal episodic memory, larger hippocampal volumes, lower amounts of free water, and lower dementia risk. Further studies are required to replicate these results among diverse samples.