Jack Caplan, Laura Vilella, Paula Lee, Roshni Nair, Deidre Dragon, Linder H. Wendt, P. Tel Eyck, Jennifer A. Ogren, Nuria Lacuey Lecumberri, Johnson P. Hampson, M.R. Sandhya Rani, Beate Diehl, Daniel Friedman, O. Devinsky, Lisa M. Bateman, Ronald M. Harper, Shiqiang Tao, Guo-Qiang Zhang, Maromi Nei, Stephan Schuele, Samden Lhatoo, George B. Richerson, Brian Gehlbach, Rup K. Sainju
BACKGROUND AND OBJECTIVES: Severe hypoxemia after generalized convulsive seizures (GCSs) can trigger neural injury and is a potential biomarker for sudden unexpected death in epilepsy (SUDEP). Some degree of variability in interbreath interval is normal, but increased variability may suggest dysfunctional breathing control and may be associated with severe postictal hypoxemia. We evaluated the relationship between interictal breathing variability and severity and duration of hypoxemia after GCS. METHODS: nadir), and secondary outcome: occurrence of combined prolonged and pronounced hypoxemia. Univariable and multivariable models were created for primary outcomes, but only univariable analyses were performed for the secondary outcome. RESULTS: = 0.002) was the only variable significantly associated with hypoxemia severity after controlling for duration of postictal generalized EEG suppression, SD-2 of the awake interbreath interval, and body mass index. Univariable analyses for combined prolonged and pronounced hypoxemia showed SD-2 of the awake interbreath interval, temporal lobe epilepsy, ictal central apnea, and a shorter tonic phase duration were significantly associated. DISCUSSION: Measures of interictal respiratory variability are associated with severe and prolonged hypoxemia after GCS. Increased interictal respiratory variability suggests baseline respiratory dysregulation in some PWE and may be a surrogate for SUDEP risk.