Matteo Conti, Davide Mascioli, Clara Simonetta, Valerio Ferrari, Jacopo Bissacco, Silvio Bagetta, Federico Carparelli, Sergio Bernardini, Francesca Di Giuliano, Enrica Marchionni, Mariangela Pierantozzi, Nicola Biagio Mercuri, Tommaso Schirinzi, Alessandro Stefani
Growing evidence suggests that the APOE ε4 allele, a genetic risk factor for Alzheimer disease (AD), influences the clinical-pathologic features of Parkinson disease (PD). APOE ε4 promotes brain amyloid accumulation, indicating a PD subtype more susceptible to late copathology. However, the early correlates of APOE ε4 carriers in PD are not known. In this study, we used a multimodal approach to define the clinical, neurochemical, and neurophysiologic profiles of APOE ε4 carriers in PD at onset.