Ida Wilkens, Sarah Bebermeier, Johanne Heine, Viktoria Ruf, Yaroslau Compta, Laura Molina‐Porcel, Claire Troakes, Albert Vamanu, S Downes, David J. Irwin, Jesse Cohen, Edward B. Lee, Christer Nilsson, Elisabet Englund, Mojtaba Nemati, Sabrina Katzdobler, Johannes Levin, Alexander Bernhardt, Alexander Pantelyat, Joseph Seemiller, S Berger, John C. van Swieten, Elise G.P. Dopper, Annemieke J.M. Rozemüller, Gábor G. Kovács, Nathaniel Bendahan, Anthony E. Lang, Jochen Herms, Günter U. Höglinger, Franziska Hopfner
BACKGROUND AND OBJECTIVES: Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by 3 core symptom complexes: parkinsonism, cerebellar syndrome, and dysautonomia. Recent Movement Disorder Society (MDS) criteria allow for the clinical diagnosis of MSA based solely on motor symptoms, without requiring dysautonomia. This study aimed to evaluate the frequency and disease trajectory of MSA patients without dysautonomia compared with those with autonomic involvement. METHODS: < 0.05. RESULTS: < 0.05). DISCUSSION: The MDS-MSA criteria expand the diagnostic scope by identifying a motor-only subgroup with a distinct and potentially slower disease course. These findings underscore the importance of including motor-only patients in natural history and interventional studies. Limitations include retrospective data collection and potential variability in symptom documentation.