Expanding the Clinical Phenotypes of Corticobasal Degeneration

Corticobasal degeneration (CBD) is a rare, progressive neurodegenerative disease associated with a variety of cognitive and motor features. International consensus criteria define 5 clinical phenotypes of CBD. It is unknown whether there are other “atypical” presentations of CBD and whether these atypical presentations have unique neuroanatomic and/or neuropathologic features. The objectives of this study were to determine whether atypical presentations of CBD exist and, if so, examine such presentations and identify neuroanatomic and histopathologic features that could account for such presentations.