Real-World Canadian Insights into Pediatric Growth Hormone Deficiency: Perspectives on Daily and Long-Acting Growth Hormone from Patients, Caregivers, and Healthcare Providers.

PURPOSE: Many patients with growth hormone deficiency (GHD) do not reach their target height in adulthood which is largely linked to treatment non-adherence. Patients report preferring a less frequent treatment regimen. Research is needed to explore reasons for non-adherence and treatment regimen preferences in patients with GHD. The purpose of this study was to explore GHD treatment preferences in health care practitioners (HCPs), patients with GHD aged 12-17 years, and caregivers of patients with GHD aged 3-17 years living in Canada. PATIENTS AND METHODS: This qualitative interview study comprised of 60-minute interviews with Canadian HCPs, adolescents with GHD, and caregivers of pediatric patients. Interviews explored treatment decisions, adherence, access barriers, and preferences between daily and once-weekly growth hormone treatment regimens. Thematic analysis of interview transcripts was conducted. RESULTS: 12 HCPs and 25 patient/caregiver interviews were completed. Limited awareness of once-weekly treatments and equity issues were observed across all participant groups. Most caregivers and patients preferred once-weekly injections for convenience and reduced burden. Emotional and logistical challenges were noted, especially for daily regimens. HCPs reported positive transitions to once-weekly regimens, though concerns remain about long-term data and coverage. Preferences leaned toward less invasive formats (e.g, pills) and medications that do not require refrigeration. CONCLUSION: This study explored experiences of Canadian GHD patients, caregivers, and HCPs, revealing strong preferences for once-weekly GH treatment due to convenience and reduced burden. Findings also highlighted gaps in treatment awareness, support, and education, emphasizing the need for targeted information and expanded patient resources.