Juliana Gomes Soares, Caroline Alves de Araújo, Giovana Dias Ramundo, Beatriz Teixeira dos Santos, Dafne Lopes Beserra Silva, Graziele Freitas de, Dayane Teixeira Ognibene, Ângela Castro Resende, Cristiane Aguiar da Costa
Abstract Propolis is a resinous substance collected by Apis mellifera bees from plant sources, characterized by a chemically diverse composition. Traditionally used for centuries in folk medicine, it has been valued for its antimicrobial, anti-inflammatory, and tissue-repairing activities, as well as for its beneficial effects in respiratory, gastrointestinal, and oral conditions. Its phytochemical profile is largely dependent on the surrounding vegetation, resulting in regional differences in bioactive constituents and, consequently, in therapeutic potential. Brazilian green propolis has garnered attention due to its purported health benefits. Although Brazilian green propolis is a well-known natural product that has been extensively investigated for its potential in respiratory diseases, particularly for its antiviral properties and its role during the COVID-19 pandemic, studies addressing its effects on metabolic disorders, such as obesity and diabetes mellitus, remain scarce. Therefore, this review aims to evaluate the potential role of Brazilian green propolis in metabolic diseases, particularly obesity and type 2 diabetes mellitus, with a focus on its antioxidant and anti-inflammatory actions.