A. Larrea, Chengxin Dai, Alejandro J. Brenes, Kathrin Korff, Benjamin A. Neely, Philipp E. Geyer, Laura F. Dagley, Richard D. Unwin, Alexandra Naba, Michael J. MacCoss, Tiannan Guo, Eric W. Deutsch, Cesar Martin, Jochen M. Schwenk, Yasset Perez-Riverol
The circulating blood proteome comprises soluble and cellular components that reflect physiological and pathological states across tissues. Advances in mass spectrometry and affinity-based proteomics have improved sensitivity and throughput, enabling the generation of public blood proteomics resources. However, comprehensive assessments of these datasets remain limited. This work reviews the cellular and molecular complexity of publicly available blood proteomics data, recent methodological developments, and the complementarity of diverse data sources across the abundance range, while outlining remaining challenges for translating blood proteomics into personalized medicine.