Combined TyG index and systemic inflammation indices as predictors for asteroid hyalosis: a hospital-based cross-sectional study.

PURPOSE: This research explored the laboratory indicators and derived indicators of patients with asteroid hyalosis (AH) in patients with diabetic retinopathy (DR), calculated the TyG index and systemic immune-inflammatory (SII) index, so as to identify the systemic pathogenic factors of AH in DR patients. METHODS: The data were gained from patients who underwent vitrectomy for proliferative DR (PDR) in Hebei Eye Hospital. Depending on the presence or absence of AH, these participants were classified into the AH group (n = 45; 27 males, 18 females) and the non-AH group (n = 90; 48 males, 42 females). The laboratory indicators, TyG index, and SII index were compared between the two groups. A statistical analysis was implemented on their age, gender, laboratory indicators, TyG index, and SII index. RESULTS: The patients in the AH group exhibited remarkably higher cholesterol (4.85 vs. 4.09 mmol/L), low-density lipoprotein (2.67 vs. 2.23 mmol/L), triglyceride (1.75 vs. 1.31 mmol/L), TyG index (9.14 vs. 8.77), and fasting blood glucose (6.95 vs. 5.82 mmol/L) levels than the patients of the non-AH group (all P < 0.05); also, the SII index (524.62 vs. 413.66), neutrophils (4.03 vs. 3.45 × 10^9/L), and platelets (256.00 vs. 222.00 × 10 ^ 9/L) significantly differed between groups (P < 0.05). However, the two groups displayed no statistically significant difference in other indicators, including white blood cells, monocytes, and glycosylated hemoglobin (P < 0.05). CONCLUSION: The abnormal lipid metabolism, inflammatory activation, and poor glycemic control in patients with AH are more pronounced than in DR patients without AH. Cerebral infarction and AH share overlapping systemic pathological mechanisms.