KEY MESSAGES: WHAT IS KNOWN : Prediagnostic corticosteroid use in Acanthamoeba keratitis has often been associated with delayed diagnosis and poor outcomes, although its independent prognostic significance remains uncertain.
WHAT IS NEW: Prediagnostic corticosteroid exposure may warrant characterization beyond a binary variable; corticosteroid agent/type and relative potency remain hypothesis-generating considerations. Keratic precipitates are nonspecific and may represent one component of the inflammatory phenotype; their prognostic significance in Acanthamoeba keratitis remains exploratory.