Psychometric properties of the Chinese version of PROMIS-29 in patients receiving kidney replacement therapy.

OBJECTIVES: The Patient-Reported Outcomes Measurement Information System-29 (PROMIS-29) is widely used to measure health-related quality of life and common symptoms, but it has not yet been validated in patients receiving kidney replacement therapy (KRT). This study aims to evaluate the psychometric properties of the Chinese version of PROMIS-29 in patients receiving KRT. METHODS: A cross-sectional survey was conducted from November 2023 to January 2024 among adult patients receiving KRT. Participants completed a clinical information questionnaire, PROMIS-29, and conventional measurement questionnaires through an online survey platform. Evaluation indicators included internal consistency, ceiling and floor effects, structural validity, convergent and discriminant validity, and criterion validity, and measurement invariance. Item characteristic curves and item information curves were also plotted. RESULTS: A total of 500 participants were included, with a age of (48.76±12.59) years. Cronbach's α coefficients for the 7 domains of PROMIS-29 ranged from 0.75 to 0.96. Confirmatory factor analysis demonstrated good model fit: Comparative fit index (CFI)=0.975, Tucker-Lewis index (TLI)=0.971, root mean square error of approximation (RMSEA)=0.046, and standardized root mean square residual (SRMR)=0.056. All dimensions met the assumption of unidimensionality. No differential item functioning was detected for the majority of items across subgroups, indicating good measurement invariance. Most items showed ideal item characteristic curves and acceptable item information curves. CONCLUSIONS: The Chinese version of PROMIS-29 has good reliability, validity, and measurement invariance among Chinese patients receiving KRT and can be used to assess health-related quality of life and symptoms in this population.