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◆ Open forum infectious diseases2026-08-01

Clinical, Molecular, and Immunological Characteristics of Scrub Typhus in Nepal.

Anurag Adhikari, Carina Münch, Nora En-Nosse, Binod Rayamajhee, Gaurab Karki, Binod Gc, Pardip Oli, Lea Fromm, Johanna Schwarz, Siddhesh Sapre, Jonas Mehl, Sagar Aryal, Dennis Tappe, Christian Keller

原始摘要(英文原文)· Original abstract
In a serologically diagnosed Nepalese scrub typhus cohort (n = 77), gastrointestinal symptoms were common. We assessed Orientia tsutsugamushi DNA in serum and performed TSA56 genotyping. Orientia DNA was detected in 10 of 77 samples (12%). TSA56 sequencing identified 4 genotypes. Polymerase chain reaction positivity was associated with diarrhea, groin lymphadenopathy, and stronger Th1-type cytokine responses.
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Clinical, Molecular, and Immunological Characteristics of Scrub Typhus in Nepal. — 科研速览 Science Skim