Kati Kebbel, Gerno Schmiedeknecht, Andrea Quaiser, Susann Schumann, Carolin Poch, Manuela Haß, Andreas Grahnert, Margarida Rodrigues, Kristin Reiche, Markus Kreuz, Ulrike Koehl
To date, prediction of manufacturing failure for CAR T cells is still lacking. In a retrospective multivariate analysis of our 368 manufactured CAR-T cell batches (tisagenlecleucel), we investigated potential factors that might be associated with manufacturing failure. In this letter to the editor, we provide a summary of our findings and outline recommendations for future advanced quality control strategies.