Association of routine laboratory parameters with chronic kidney disease-mineral and bone disorder in patients on maintenance hemodialysis: A retrospective study.

ObjectiveTo investigate the associations between routine laboratory parameters and chronic kidney disease-mineral and bone disorder (CKD-MBD) in patients on maintenance hemodialysis (MHD).MethodsThis retrospective study collected data on demographic characteristics, medication interventions, and routine laboratory parameters from patients on MHD treated at the First Affiliated Hospital of Nanchang University in September 2025. Patients were classified into the CKD-MBD abnormal group if any of the following parameters exceeded the KDOQI guideline-recommended ranges: corrected serum calcium, serum phosphate, or parathyroid hormone (PTH). Patients with all three parameters within the recommended ranges were assigned to the CKD-MBD normal group. Differences in demographic characteristics, medication interventions, and laboratory parameters between groups were analyzed using SPSS version 25. Binary logistic regression analysis was performed to identify factors associated with CKD-MBD.ResultsA total of 546 patients were included, of whom 167 were classified into the CKD-MBD normal group and 379 into the abnormal group, yielding a prevalence of CKD-MBD abnormalities of 69.41%. Multivariate logistic regression analysis showed that, compared with patients with a dialysis vintage >10 years, those with a dialysis vintage <5 years had a significantly lower risk of CKD-MBD biochemical abnormalities (OR = 0.329, P = 0.002). Additionally, serum potassium (OR = 1.489, P = 0.011) and C-reactive protein (OR = 1.050, P = 0.015) were significantly associated with an increased risk of CKD-MBD.ConclusionCKD-MBD is highly prevalent among patients on MHD. Longer dialysis vintage, elevated serum potassium, and increased C-reactive protein may be associated with a higher risk of CKD-MBD. In clinical practice, in addition to managing CKD-MBD by regulating the "calcium-phosphate-parathyroid hormone" axis, attention should also be given to dialysis vintage, serum potassium, and C-reactive protein to facilitate comprehensive CKD-MBD management.