◆ Journal of Clinical Investigation2026-01-13· Biology
Detection of clonal hematopoiesis of indeterminate potential via genome or exome sequencing underestimates disease associations
Robert W. Corty, Yash Pershad, J. Brett Heimlich, Caitlyn Vlasschaert, Leo Luo, Taralynn Mack, K. Amancherla, Cassianne Robinson-Cohen, Michael R. Savona, Alexander G. Bick
原始摘要（英文原文）· Original abstract
Epidemiology studies underestimate the strength of the association between clonal hematopoiesis and disease due to false negatives from shallow, whole-genome sequencing versus deep targeted sequencing.