Wenjie Wu, Lavanya Challagundla, Andrew R. Milner, Michael R. Garrett, Ashley Johnson
, specifically within the context of experimental hypertension (AngII or DOCA), plays a role in regulating blood pressure at the systemic or kidney-specific level. A slight protective effect on blood pressure and kidney injury for DOCA knockout models was observed, replicating the rat knockout. However, the large effect in the rat model is likely explained by the highly permissive genetic background of the Dahl SS model.