Guilherme da Silva Rodrigues, Natália Yumi Noronha, Jonas Benjamim, Andressa Crystine da Silva Sobrinho, Ivo Vieira de Sousa Neto, Chanachai Sae-Lee, Pitaksin Chitta, Takuji Kawamura, Fernando Barbosa Júnior, Carla Barbosa Nonino, Lígia Moriguchi Watanabe, Carlos Roberto Bueno Junior
This study integrates genome-wide genotyping, DNA methylation, and transcriptomic validation to reveal genetic and epigenetic determinants of muscle strength in postmenopausal women. We identify novel SNPs, a predictive polygenic risk score, and higher BMP1 epigenetic scores linked to greater muscle strength and bone remodeling pathways. These multiomics insights provide potential biomarkers for musculoskeletal aging and targets for strategies to preserve strength and skeletal health in older women.