Human motor memory retention requires fronto-parietal circuit plasticity

This study provides direct evidence of motor learning-related plasticity in a cortical circuit involving sensory areas in rostral parietal cortex and premotor areas in frontal cortex. Using a visuomotor adaptation paradigm with cTBS, disruption of rostral parietal or dorsal premotor cortex impairs retention, whereas disruption of primary motor cortex does not. Disrupting both regions together causes no additional impairment, suggesting an interconnected learning circuit in humans and advancing understanding of cortical substrates of motor learning.