Moderate hyperthermia impairs dynamic cerebral autoregulation but not its directional sensitivity

Using a multimetric approach combining transfer function analysis with absolute and normalized directional sensitivity metrics, we show that moderate hyperthermia impairs dynamic cerebral autoregulation while preserving its directional sensitivity. Notably, asymmetry in the cerebral pressure-flow relationship was evident at both 0.05 and 0.10 Hz when using the normalized metric, despite heat-induced reductions in dynamic buffering. These findings suggest that distinct mechanisms govern the dynamic and directional components of cerebral autoregulation.