Gavin Power, Min Jeong Cho, Jesús H. Beltrán-Ornelas, Marc A. Augenreich, Natnicha Imkaew, Olubodun Michael Lateef, Francisco Ramírez-Pérez, Larissa Ferreira-Santos, Camila Manrique-Acevedo, Luis A. Martinez-Lemus, Jaume Padilla
Impaired flow-mediated dilation (FMD) is an indicator of endothelial dysfunction in type 2 diabetes (T2D). However, the exact cellular and molecular mechanisms contributing to impaired mechanotransduction of shear stress in T2D are incompletely understood. This work supports the novel concept that increased endothelial activity of a disintegrin and metalloproteinase 17 (ADAM17) causes cleavage of cell-surface CD44, leading to loss of hyaluronan (HA)-associated shear stress mechanotransduction.