Emely Henriquez Pilier, Jacqueline-Yvonne Cephus, Shelby N Kuehnle, Elie Tannous, Alessandra Tomasello, Kaitlin E McKernan, R. Stokes Peebles, Katherine N. Cahill, Jeffrey C. Rathmell, Dawn C. Newcomb
Estrogen receptor-alpha (ER-α) signaling increased obesity and allergen-induced airway inflammation in mice. In addition, women with obesity and asthma had increased circulating Th17 cells compared with men with obesity and asthma. These findings provide mechanistic insights into the intersection of obesity, sex hormones, and airway inflammation-underscoring the importance of personalized approaches to managing individuals with obesity and asthma.