Brief repetitive pressure overload in mice induces eccentric remodeling and impaired contractile reserve

This study introduces a novel murine model of RPO using serial phenylephrine infusions to mimic chronic episodic hemodynamic stress. Unlike porcine models of RPO that demonstrate increased LV chamber stiffness and protection against strain-induced myocyte injury, mice exhibit reduced LV chamber stiffness and persistent myocyte apoptosis that is accompanied by loss systolic dysfunction with a preserved ejection fraction at rest. These findings indicate important species differences in the response to transient pressure overload.