Andre Heinen, André Spychala, Lucas Ballmann, Stefanie Gödecke, Zewa Faradj, Florian Bresch, Martina Krüger, Katharina Bottermann, Heba Zabri, J.W. Fischer, Patrick Petzsch, A. Gödecke
Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome whose pathophysiological mechanisms are incompletely understood, potentially due to a lack of preclinical models reflecting the broad range of pathophysiological aspects. We describe a diabetic DIO-STZ mouse model showing a pronounced HFpEF with underlying mechanisms that remarkably differ from other HFpEF models, making this model a relevant extension of the range of HFpEF models, especially for investigating molecular mechanisms or therapeutical interventions in diabetes.