Michiel RL Tubeeckx, Tijs Bringmans, Bo Goovaerts, Siel Van den Bogaert, M Grootaert, Elizabeth AV Jones, Petra Korpisalo, Greta Juusola, Galina Wirth, Samuel L. Murphy, H Heidbuchel, Gilles W. De Keulenaer, V Segers
JK07 was able to prevent the increase in microvascular resistance in a DOCA-induced hypertensive pig model, as measured by the bolus thermodilution method.
CMD is implicated in numerous cardiac diseases, for which only a few therapeutic options are available. Stimulation of the ERBB4/NRG1 pathway has shown beneficial effects in preclinical models of heart failure. JK07 is a selective ERBB4 agonist of interest. JK07 was able to prevent the increase in microvascular resistance in a DOCA-induced hypertensive pig model, as measured by the bolus thermodilution method.