Warda Merchant, Arely Salazar Tinajero, A. RAUF KHAN, Yi Chu, Sanaz Saleh, Dana Tasabehji, Donald A. Morgan, Kevin W. Williams, Kamal Rahmouni, Mohamad Mokadem, Laurent Gautron
Roux-en-Y gastric bypass in obese mice triggered markers of vagal nerve injury, reduced Glp1r-expressing vagal afferents, and lowered Glp1r mRNA in the nodose ganglion. Nerve injury experiments reproduced these effects. Despite reduced receptor expression, GLP1R agonist-evoked vagal firing was exaggerated after RYGB or vagal injury. Overall, the findings indicate RYGB causes vagal neuropathy with diminished Glp1r expression but heightened GLP1 sensitivity.