Plasma extracellular vesicle signatures of metabolic health and exercise response in a pilot study of older adults

Specific plasma EV biomarkers related to immune subsets, skeletal muscle, and mesenchymal stem cells were associated with better indices of insulin action at baseline. High-volume, vigorous-intensity aerobic exercise increased many of these insulin action-related EV subpopulations. We developed a novel, minimally invasive platform that uses plasma EV surface markers to assess metabolic health and exercise responsiveness. This platform is ready for validation in larger human cohorts, including the full STRRIDE cohort.