Angela Bruzina, William T. Juckett, Faezeh Mozafari, Carlee G. Freeman, Jarrod A. Call, Sarah M. Greising
This study combined ovariectomy and volumetric muscle loss injury model to investigate if ovarian hormones play a protective role in females during the sequelae of traumatic skeletal muscle injury. The loss of ovarian hormones induces whole body and cellular metabolic inflexibility and worsened functional recovery, identifying ovarian hormones as key regulators of VML-induced metabolic pathophysiology.