Minying Cui, Sebastian Edman, Baptiste Jude, Paulo R. Jannig, Oscar Horwath, Emily Shorter, Pieter J Koopmans, Toby L. Chambers, Ronald G. Jones, Abraham Nilsson, Johanna T. Lanner, Thomas Sejersen, Eva Pontén, Kevin A. Murach, Jörg Schilcher, Ferdinand von Walden
Our findings establish ribosome biogenesis and ribosome remodeling as core components of the skeletal muscle regenerative program conserved across species. The rapid, MYC-driven induction of translational capacity, coupled with a transient switch in ribosomal protein composition, increases ribosome heterogeneity during skeletal muscle regeneration.