Florian Nima Fleckenstein, Dina David, Paolo Garducci, Tazio Maleitzke, Stephan Oehme, Lynn Jeanette Savic, Timo Alexander Auer, Bernhard Gebauer, Tobias Winkler, Federico Collettini
< .001), corresponding to a median reduction of 4 points (95% CI: 3.5, 4.0). At 12 months, 55%-80% of participants achieved improvements exceeding the MCID across all KOOS subscores. Conclusion GAE using RRGMs is safe and is associated with clinically meaningful improvement in participants with OA-related knee pain. © The Author(s) 2026. Published by the Radiological Society of North America under a CC BY 4.0 license.