Rashi I Mehta, Tianhao Wang, Aubrey Lewis, Claire E Walker, Caroline Gebczak, Lisa L Barnes, David A Bennett, Rupal I Mehta
Participants died at mean age of 90.62 (SD = 6.98) years. β-amyloid (odds ratio [OR], 0.79 [95% confidence interval {CI}, 0.66-0.95]) and neurofibrillary tangles (OR, 0.84 [95% CI, 0.71-0.98]) inversely associated with AG count. β-amyloid (OR, 0.78 [95% CI, 0.65-0.92]) and B (Braak) score (OR, 0.80 [95% CI, 0.66-0.96]) inversely associated with AG patch count. Linear type AG in frontal (OR, 1.46 [95% CI, 1.03-2.07]) and parietal (OR, 1.57 [95% CI, 1.02-2.43]) regions was associated with higher odds of dementia.
INTRODUCTION: Arachnoid granulations (AG) prominently enlarge with age, yet limited studies evaluate AG in neurodegeneration. Here, we investigate the associations of AG morphologies with Alzheimer's disease (AD).
METHODS: Macroscopic AG properties were evaluated along dorsal post mortem brain specimens (n = 882). Regression models were used to analyze their associations with AD neuropathology and dementia, adjusting for demographics.
RESULTS: Participants died at mean age of 90.62 (SD = 6.98) years. β-amyloid (odds ratio [OR], 0.79 [95% confidence interval {CI}, 0.66-0.95]) and neurofibrillary tangles (OR, 0.84 [95% CI, 0.71-0.98]) inversely associated with AG count. β-amyloid (OR, 0.78 [95% CI, 0.65-0.92]) and B (Braak) score (OR, 0.80 [95% CI, 0.66-0.96]) inversely associated with AG patch count. Linear type AG in frontal (OR, 1.46 [95% CI, 1.03-2.07]) and parietal (OR, 1.57 [95% CI, 1.02-2.43]) regions was associated with higher odds of dementia.
DISCUSSION: Select AG morphologic properties associate with AD outcomes. Future studies should explore mechanisms underlying these associations.