Fluid Mechanics of Blood Cells and Vesicles Squeezing Through Narrow Constrictions

The squeezing of blood cells and vesicles through narrow constrictions, such as splenic slits, pulmonary capillaries, vascular endothelial gaps, and microfluidic channels, is crucial in physiology and biotechnology, with fluid mechanics playing a central role. The diverse geometries of these constrictions, the associated flow conditions, and the unique mechanical properties of cells and vesicles create a rich subject in fluid mechanics emerging from nonlinear dynamics of fluid–structure interactions involving both lubrication and Marangoni flows. Advances in microfluidics, video microscopy, and computational modeling have enabled investigations into these complex processes. This review surveys the key features and approaches, recent prominent studies, and unresolved challenges related to these processes, offering insights for researchers across biomechanics, biomedical engineering, biological physics, hematology, physiology, and applied mathematics.