Jixuan Ma, Peter G J Burney, David M Mannino, Christer Janson, Thorarinn Gíslason, Daniel O Obaseki, Rain Jõgi, Valentina Quintero Santofimio, James Potts, Abdul Rashid, Gregory E Erhabor, Rune Nielsen, Ali Kocabas, Asaad Nafees, Rana Ahmed, Meriam Denguezli, Cristina Barbara, Joao Cardoso, Herminia Brites Dias, Fátima Rodrigues, Dhiraj Agarwal, Sanjay Juvekar, Frits M E Franssen, Terence Seemungal, Kevin Mortimer, Mohammed El Biaze, Padukudru Anand Mahesh, Parvaiz Koul, Michael Studnicka, Andre F S Amaral, BOLD Collaborative Research Group, k
This study estimated birth cohort effects on lung function using BOLD (Burden of Obstructive Lung Disease) data from 28 569 adults born between 1902 and 1976 across 41 sites in 34 countries. Forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1) and the FEV1/FVC increased across successive birth cohorts in both high-income countries (HICs) and low- and middle-income countries (LMICs), with mean values rising steadily with later birth year. In fully adjusted models, FVC increased by 21.4 mL, FEV1 by 24.6 mL and FEV1/FVC by 0.25% per birth year. These positive associations were consistent across sex, smoking status and country-income subgroups (HICs and LMICs).