Agnès B. Jousset, Delphine Girlich, Saoussen Oueslati, Aurélien Birer, Anne Delaval, Caroline Guyot, Inès Rezzoug, Cécile Emeraud, Thierry Naas, Rémy A. Bonnin, L Dortet
ABSTRACT Resistance to ceftazidime-avibactam (CAZ-AVI) is a growing problem. This study describes the selection of CMY-219, a CMY-42 variant (G156D), conferring resistance to CAZ-AVI in an OXA-484-producing Escherichia coli ST410 after treatment. It raises concern about the risk of selection of CMY variants under CAZ-AVI exposure in ST410 and related clones, which commonly carry CMY-42, are prone to carbapenemase acquisition, and harbor modified PBP3.