Diogo Pinheiro Cordeiro, Thomas A Nelson, Christopher S Graffeo, James Battiste, David R Miller
Brain tumors remain among the most challenging malignancies, necessitating advances in diagnostic accuracy and treatment precision. Integrated multimodal surgical platforms combining structural, functional, and molecular data are transforming neuro-oncology by improving surgical planning, intraoperative guidance, and patient monitoring. This perspective reviews current and emerging imaging modalities including optical techniques and AI-integrated platforms, while discussing their integration within unified clinical workflows that may advance personalized brain tumor care and surgical outcomes.