The tissue-specific regulation of immunobiology by IL-17 signaling

IL-17 family cytokines are central regulators of tissue immunity. Here, we review recent advances in defining the cell- and tissue-specific activities of IL-17, emphasizing the signaling pathways engaged by IL-17 receptor (IL-17R) complexes and their associated downstream pathways. We highlight the intersecting transcriptional and posttranscriptional mechanisms that determine IL-17-driven responses and that underlie functional diversity across tissues. Last, we discuss emerging roles for IL-17 signaling in immunometabolism, neuroimmune interactions, cancer, and the latest approaches for targeted therapies.