Functional Specialization and Collaboration of <scp>cDC2</scp> Subsets in <scp>CD4</scp> + T Cell Priming and Differentiation

Dendritic cells (DCs) play a crucial role in bridging innate and adaptive immunity by presenting antigens to prime antigen-specific T cells. Conventional DC (cDC) type 2 cells (cDC2s) are a phenotypically heterogeneous population of DCs highly capable of presenting antigens to CD4+ T cells. Studies found functional differences between different cDC2 subsets in regulating effector CD4+ T helper (Th) cells, but collaboration between different cDC subsets has also been suggested. In this review, we discuss recent advances in understanding the subset-specific role of cDC2s in regulating Th cells.