Serum Omentin-1 and CS846: Biomarkers for diagnosis and post-TKA functional outcomes in knee osteoarthritis.

BACKGROUND: To determine the synergistic diagnostic value of serum Omentin-1 and cartilage oligomeric matrix protein epitope CS846 (CS846) in knee osteoarthritis (KOA) and to explore their link to functional recovery following total knee arthroplasty (TKA), thereby contributing to improved early screening and prognostic strategies. METHODS: Osmislili smo prospektivnu kohortnu studiju koja je obuhvatila 84 ispitanika (42 sa KOA i 42 zdrave kontrole). Tehnika enzimski povezanog imunosorbentnog testa (ELISA) korisćena je za merenje serumskog omentina-1, CS846 i inflamatornih indeksa (hs-CRP i ESR). ROC krive (Receiver Operating Characteristic) odredile su dijagno-stičku efikasnost, a za kombinovanu dijagnozu je uspostav-ljen logistički regresioni model. Funkcionalni ishodi, mereni WOMAC rezultatima, i status rehabilitacije su pregledani 6 meseci nakon operacije. RESULTS: Analysis revealed reduced Omentin-1 and elevated CS846 in KOA patients versus controls. The diagnostic per-formance (AU C= 0.851) of the biomarker combination surpassed that of individual tests. Patients with KL1-2 grades exhibited elevated Omentin-1 but lower CS846 levels compared to those with KL3-4 grades (P< 0.05). An inverse correlation was observed between Omentin-1 and inflammatory markers (hs-CRP ESR), contrasting with the positive correlation for CS846. Post-treatment, poor recov-ery was associated with more pronounced decreases in Omentin-1 and increases in CS846 (P< 0.05). The COM-bined model effectively predicted suboptimal rehabilitation outcomes (AU C= 0.857). CONCLUSIONS: The synergistic use of serum Omentin-1 and CS846 biomarkers boosts early detection capability for KOA while accurately forecasting post-TKA functional out-comes.