Aisling McCarthy, Uffe Søholm, Natalie Zaremba, Frans Pouwer, Allan Vaag, Simon Heller, Julia K. Mader, Ulrik Pedersen‐Bjergaard, Bastiaan E. de Galan, Éric Renard, Mark L. Evans, Rory J. McCrimmon, Stephanie A. Amiel, Pratik Choudhary, Patrick Divilly
Hypoglycaemia is a common complication of insulin therapy. The relationship between hypoglycaemia and mood is not well understood, with conflicting evidence reported in the literature [1, 2]. Potential explanations for these conflicting data include the variation in hypoglycaemia definitions and thresholds. The strongest associations between hypoglycaemia and mental health appear to relate to severe hypoglycaemia (SH) [3], with impaired awareness of hypoglycaemia (IAH) being a major risk factor [4]. Using the dataset with which we previously demonstrated an association between IAH and a mental health burden [5], this study provides an opportunity to explore whether this link operates through increased exposure to hypoglycaemia, using different common definitions of hypoglycaemia.