When Binding Is Not Blockade: Interpreting <scp>IgG4</scp> ⁺ T Cells After <scp>PD</scp> ‐1 Therapy

IgG4 positivity on circulating T cells after PD-1 therapy may indicate residual antibody binding rather than sustained functional PD-1 blockade. During sequential ramucirumab plus docetaxel plus G-CSF treatment, peripheral IgG4+ T-cell dynamics may also be influenced by redistribution and treatment-related confounders, limiting direct inference about effective intratumoral antitumor immunity.