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◆ British journal of haematology2026-08-16

Effect of efgartigimod IV on immature platelet fraction in primary immune thrombocytopenia in the ADVANCE IV trial.

Hanny T Al-Samkari, Filip Matthijssens, Kaichi Nishiwaki, Francesco Zaja, Sylvian Audia, Yoshitaka Miyakawa, Jaume Ayguasanosa, Damien Chimits, Anna Hultberg, Peter Ulrichts

原始摘要(英文原文)· Original abstract
Elevated percentage of immature platelets is indicative of consumptive thrombocytopenic disorders. In immune thrombocytopenia, low platelet counts may result from reduced production or increased degradation, both driven by IgG autoantibodies. By blocking FcRn, efgartigimod decreases immature platelet fraction, likely by reducing platelet degradation through decreased IgG autoantibody levels.
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Effect of efgartigimod IV on immature platelet fraction in primary immune thrombocytopenia in the ADVANCE IV trial. — 科研速览 Science Skim