Association between glomerular filtration rate and comprehensive geriatric assessment parameters in older adults.

BACKGROUND/AIM: This study aimed to investigate the association between estimated glomerular filtration rate (eGFR) and a wide range of geriatric syndromes assessed by comprehensive geriatric assessment (CGA) in older adults. METHODS: In this retrospective cross-sectional study, 1346 patients aged ≥ 60 years who underwent CGA in geriatric inpatient and outpatient clinics of a tertiary care hospital between January 2023 and January 2026 were included. Participants were categorized into four groups according to eGFR levels (≥ 90, 60-89, 30-59, and < 30 mL/min/1.73 m2). Geriatric syndromes-including frailty, sarcopenia, functional dependence, cognitive impairment, malnutrition, falls, urinary incontinence, depression risk, and polypharmacy-were systematically evaluated. Associations between eGFR and CGA parameters were analyzed using correlation and logistic regression models. RESULTS: Lower eGFR levels were significantly associated with older age, greater comorbidity burden, and increased medication use (all p < 0.001). Significant correlations were observed between eGFR and multiple CGA domains, including functional status, physical performance, frailty, sarcopenia, nutritional and cognitive status, falls, urinary incontinence, and polypharmacy (all p < 0.05). In adjusted analyses, low eGFR (< 60 mL/min/1.73 m2) remained independently associated with higher comorbidity burden, frailty, impaired gait speed, and polypharmacy. Depression risk was not consistently associated with reduced eGFR. CONCLUSION: Reduced eGFR is independently associated with a higher burden of geriatric syndromes. Integrating CGA into routine care may enable early detection and multidisciplinary management to improve clinical outcomes in older adults with impaired kidney function.