Sex-stratified analysis of the potential association between PGLYRP2 rs892145 variant and Parkinson's disease across diverse ancestral populations

Variants in PGLYRP2, particularly rs892145-T, have been suggested as Parkinson's disease (PD) risk factors. We analyzed data from 48,458 PD patients and 24,670 controls across diverse ancestries. Contrary to previous findings on smaller datasets, no significant sex-dependent effect of rs892145-T was observed across all ancestries. Gene-based analyses identified another variant, rs959117-T, as nominally associated with PD in AAC females (OR=0.65, 95\%CI:0.50-0.85, p=1.70E-03), but it did not survive correction for multiple testing (Bonferroni p=0.10). Overall, our results show no association between PGLRYP2 and PD.