Rachel M. Petersen, Robert L. Tennyson, Tan Bee Ting A P Tan Boon Huat, Kar Lye Tam, Marina M. Watowich, Izandis bin Mohd Sayed, Colin Nicholas, Kamal Solhaimi Fadzil, Kee Seong Ng, Yvonne Ai Lian Lim, Vivek V. Venkataraman, Ian J. Wallace, Thomas S. Kraft, Amanda J. Lea
Early life environments can have long-lasting impacts on health and fitness, but the evolutionary significance of these effects remains debated. Two major classes of explanations have been proposed: developmental constraint (DC) explanations posit that early life adversity limits optimal development, leading to long-term costs, while predictive adaptive response (PAR) explanations posit that organisms use early life cues to predict adult conditions, resulting in detriments when adult environments do not match expectations. We tested these hypotheses using anthropological and biomedical data for the Orang Asli-the Indigenous peoples of Peninsular Malaysia-who are undergoing a rapid but heterogeneous transition from non-industrial, subsistence-based livelihoods to more industrialized, market-integrated conditions. Using questionnaire data, we show that this shift creates natural variation in the degree of similarity between early life and adult environments. Using anthropometric and health data, we find that more rural, subsistence-based early life environments are associated with shorter stature but better adult cardiometabolic health. Applying a quadratic regression framework, we find support for DC but not PAR in explaining adult cardiometabolic health, echoing findings and conclusions from other long-lived species. Overall, our results suggest that non-industrialized early life conditions can provide additive protection against common health issues associated with urban, industrialized lifestyle exposure.