Habibatou Diabate, Clifton Mason Perry, Sajidha Nizamudeen, Oluwatobi Onalaja, Sabah Fatima, Ram Vikas Reddy, Mohammed Hady Albitar, Abdullah Almahmoud, Alana Rivera Negrón, Harsh Vijay Sanghvi, Mohammed Abdul Mateen
Obesity is associated with hepatic dysfunction, chronic inflammation and vitamin D deficiency, but their interrelationship remains incompletely understood. Therefore, it is of interest to compare the liver function, inflammatory and vitamin D-PTH biomarkers between 100 obese adults (BMI ≥30 kg/m2) and 100 age-matched non-obese controls. Obese participants showed significantly higher ALT, AST, ALP, GGT, CRP, IL-6, fibrinogen and PTH levels, with lower serum 25(OH)D concentrations. Regression analysis identified CRP (OR=1.38, 95% CI: 1.24-1.54) and GGT (OR=1.35, 95% CI: 1.20-1.52) as the strongest positive predictors, while 25(OH)D showed a significant inverse association with obesity (OR=0.79, 95% CI: 0.68-0.91). Thus, data shows the combined contribution of hepatic dysfunction, systemic inflammation and vitamin D imbalance to obesity-related metabolic disturbances and support their early clinical assessment.