18F-FDG Uptake Outperforms 68Ga-FAPI in Mediastinal NUT Carcinoma

NUT carcinoma is a rare and highly aggressive tumor with nuclear protein in the testis gene rearrangement. Herein, we describe the different findings of 68 Ga-FAPI-04 and 18 F-FDG PET/CT in a 31-year-old man with mediastinal NUT carcinoma with lymph node and pleura metastasis. In our case, 68 Ga-FAPI-04 PET/CT was not superior to FDG in detecting primary lesions and lymph node metastases of mediastinal NUT, but it is possible to produce beneficial value in the evaluation of pleura metastasis.