Small intestine choriocarcinoma with brain, lung and liver metastases in a male patient: a case report.

INTRODUCTION: Extragonadal non-gestational choriocarcinama, especially in the gastrointestinal tract, is exceptionally rare. It often presents with metastatic disease and nonspecific symptoms, leading to diagnostic delays. CASE REPORT: Herein, we reported a 61-year-old male patient diagnosed with small intestine choriocarcinoma with metastases of brain, lung, liver and lymph nodes. This patient presented initially with black stools, heart palpitations and chest tightness. After diagnosis, the patient received chemotherapy with etoposide and cisplatin. The patient demonstrated a robust clinical and biochemical response to chemotherapy, with a significant reduction in β-HCG levels and increase of hemoglobin. Follow-up imaging demonstrated a decreased size of pulmonary and liver metastases. CONCLUSIONS: Because of the complex nature of extragonadal non-gestational choriocarcinama, diagnosis is often delayed. The present case highlight the necessity for high clinical suspicion, and early initiation of treatment.